Was the new finger a 'natural' miracle?
Added: Thu, 01 May 2008 23:00:00 UTC
Thanks to Joe Running for the link.
Was the new finger a 'natural' miracle?
By Caroline Parkinson
Health reporter, BBC News
The story of the man who re-grew a finger using "pixie-dust" has captured the imagination of many this week.
But a number of scientists have cast cold-water over the claims - and said it may have been a "natural" miracle.
Lee Spievak, 69, chopped off part of his finger - said to be almost down to the first joint - in a model aeroplane accident in 2005.
His brother was working in the field of regenerative medicine, with Dr Stephen Badylak at the University of Pittsburgh.
They provided Mr Spievak, who lives in Cincinnati, Ohio, with the "pixie-dust" - more accurately called extracellular matrix, which he sprinkled on his finger.
Extracellular matrix is, essentially, the support structure for cells which is present in all animal and human tissue.
Within weeks, it is said the tip of the finger - including bone, tissue, skin and nail grew back.
'A common-or-garden injury'
Dr Badylak's team had previously been working on regenerating much simpler biological structures using the extracellular matrix.
That is something that numerous teams of scientists across the world have been pursuing for decades.
Extracellular matrix is just one of the "scaffolds" for supporting new cell growth.
But re-growing a fingertip would be a significant step forward.
Professor Stephen Minger, an expert in stem cell and regenerative medicine at Kings College London, said: "This is where my scepticism comes in. It would be a really complex task.
"At the moment people are trying to figure out how to make heart, brain and liver cells.
"I don't see how they could re-grow a fingertip by sprinkling on extracellular matrix."
Mr Spievak says he has regained feeling in his finger.
But Professor Minger said: "When people have a fingertip reattached, the nerves don't re-grow and people have no sense of pressure, or of pain."
'A remarkable process'
Scientists say they want to see research by Dr Badylak published in peer-reviewed journals - which means work has been assessed by other experts - rather than simply hearing anecdotal reports.
Simon Kay, professor of hand surgery at the University of Leeds said he suspected that Mr Spievak had sustained a "very common-or-garden, mundane fingertip injury" which had not affected the bone or led to the loss of the nail.
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