More clues in the genetics of schizophrenia
By DAVID CYRANOSKI - NATURENEWS
Added: Wed, 02 Nov 2011 14:09:32 UTC
Chinese researchers add three chromosomal regions to a slow-growing list of genetic links.
Two of the largest studies yet carried out on the genetics of schizophrenia in Chinese populations have turned up three genetic loci, or chromosomal regions, previously not known to be related to the disease.
These genome-wide association studies (GWAS), done independently and published in Nature Genetics on 30 October1,2, also begin to redress a geographical imbalance: until now, GWAS have focused mainly on Western populations.
Roughly 1 in 100 people will suffer from schizophrenia in their lifetimes, which is considered largely heritable (up to 80%). But this genetic influence seems to be produced by hundreds of variations in DNA, each of which increases risk by a small amount. Researchers have so far found some 20 such variants, but have been unable to pin down the exact genes that are affected by those variations or molecular mechanisms that cause the disease.
Richard A. Friedman, M.D. - The New... 32 Comments
Depression Defies the Rush to Find an Evolutionary Upside
- - Med 2 Comments
Human memory has historically defied precise scientific description, its biological functions broadly but imperfectly defined in psychological terms. In a pair of papers published in the November 2 issue of The Journal of Neuroscience, researchers at the University of California, San Diego report a new methodology that more deeply parses how and where certain types of memories are processed in the brain, and challenges earlier assumptions about the role of the hippocampus.
- - medicalxpress.com 10 Comments
Researchers at Stanford University School of Medicine have been able to switch on, and then switch off, social-behavior deficits in mice that resemble those seen in people with autism and schizophrenia