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Jos, thanks for the precise mathematical definition. I hadn't seen that before, but if I was going to formulate a definition, "in the limit as frequency goes to zero" captures precisely what I was saying -- that it is in terms of the "rarer" alleles -- those with low frequency. Relatedness gives exact probabilities for a brand spanking new mutation. It is a very good approximation for low frequency alleles.
Permalink Tue, 31 Aug 2010 21:51:48 UTC | #508855